解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:OBJECTIVE:To examine the economic burden of myelodysplastic syndromes (MDS) and the incremental cost of transfusion dependence. RESEARCH DESIGN AND METHODS:Adults with evidence of MDS were identified between 05/01/2000 and 09/30/2003 from a longitudinal, retrospective claims database for a large, geographically divers...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007990903076699
更新日期:2009-08-01 00:00:00
abstract:AIM:To assess the efficacy of a strategy to improve vascular risk management in patients with type 2 diabetes mellitus (T2DM). METHODS:This was a pilot best practice implementation enhancement programme that enrolled 578 patients with T2DM. A baseline visit was followed by a concerted effort from previously trained ph...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007990903073035
更新日期:2009-08-01 00:00:00
abstract:OBJECTIVE:Neuropathic pain is often difficult to treat due to a complex pathophysiology. This study evaluated the efficacy, tolerability and safety of combination therapy with 5% lidocaine medicated plaster and pregabalin for neuropathic pain in patients with post-herpetic neuralgia (PHN) or painful diabetic polyneurop...
journal_title:Current medical research and opinion
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1185/03007990903048078
更新日期:2009-07-01 00:00:00
abstract:OBJECTIVE:To perform an open, non-controlled, multiple-dose, international, multicentre, phase III study to evaluate epoetin zeta, a biosimilar epoetin referenced to epoetin alfa, for the treatment of chemotherapy-induced anaemia in patients with cancer. METHODS:Safety, tolerability and efficacy of subcutaneously admi...
journal_title:Current medical research and opinion
pub_type: 杂志文章,多中心研究
doi:10.1185/03007990903050876
更新日期:2009-07-01 00:00:00
abstract:BACKGROUND:For the prevention of chemotherapy-induced febrile aplasia, a single injection of pegfilgrastim per cycle has the same efficacy as six to ten injections of conventional granulocyte colony-stimulating factor (G-CSF). However, there are few data on the economic impact of pegfilgrastim use, especially in the co...
journal_title:Current medical research and opinion
pub_type: 杂志文章,多中心研究
doi:10.1185/03007990902918156
更新日期:2009-06-01 00:00:00
abstract:OBJECTIVE:To review the pharmacoeconomic literature evaluating use of antihistamines in treating allergic rhinitis (AR) in the US. METHODS:Three independent reviewers conducted a comprehensive search of the current literature with PubMed. They identified articles describing original research comprising US cost analyse...
journal_title:Current medical research and opinion
pub_type: 杂志文章,评审
doi:10.1185/03007990902875992
更新日期:2009-06-01 00:00:00
abstract:OBJECTIVE:To investigate whether gum chewing affects perceived levels of everyday stress among persons who (1) regularly chew gum or (2) do not chew gum on a regular basis. RESEARCH DESIGN AND METHODS:Two Internet-based studies were conducted. Study 1 enrolled participants who chewed gum > or =4 days per week, chewed ...
journal_title:Current medical research and opinion
pub_type: 杂志文章,随机对照试验
doi:10.1185/03007990902959283
更新日期:2009-06-01 00:00:00
abstract:OBJECTIVE:Ramelteon is an MT(1)/MT(2) melatonin receptor agonist indicated for the treatment of insomnia characterized by difficulty with sleep onset. In previous clinical studies, ramelteon reduced latency to persistent sleep (LPS) in subjects with chronic insomnia. The goal of the current analysis was to determine th...
journal_title:Current medical research and opinion
pub_type: 杂志文章,meta分析
doi:10.1185/03007990902858527
更新日期:2009-05-01 00:00:00
abstract::Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia seen in clinical practice and has attracted much attention due to its association with a substantial mortality and morbidity, particularly from stroke, thromboembolism and heart failure. This Editorial Commentary provides a brief overview of the ...
journal_title:Current medical research and opinion
pub_type: 评论,社论
doi:10.1185/03007990902910443
更新日期:2009-05-01 00:00:00
abstract:OBJECTIVE:To determine the characteristics of asthma (A) and allergic rhinitis (AR) among asthma patients in primary care practice. RESEARCH DESIGN AND METHODS:Primary care physicians, pulmonologists, and allergologists were asked to recruit consecutive asthma patients with or without allergic rhinitis from their dail...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007990902820733
更新日期:2009-05-01 00:00:00
abstract:OBJECTIVE:Thiazide diuretics such as hydrochlorothiazide (HCT) are a widely used first-line treatment for hypertension, but most patients will not achieve blood pressure (BP) control with HCT alone and so will require combination therapy. In this study the efficacy, safety and tolerability of a single-pill combination ...
journal_title:Current medical research and opinion
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1185/03007990902804158
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVE:Most registration studies for new osteoporosis drugs have used a combination of quantitative morphometry (QM) and visual semiquantitative reading (SQ) to define vertebral fractures. However, in the pivotal teriparatide Fracture Prevention Trial (ClinicalTrials.gov Identifier: NCT00670501), vertebral fractures...
journal_title:Current medical research and opinion
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1185/03007990902790993
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVE:To evaluate intraocular pressure (IOP)-lowering efficacy, tolerability, and safety of the fixed combination of bimatoprost 0.03% and timolol 0.5% (Ganfort) among German patients. METHODS:Multicenter, observational, open-label study of patients with primary open angle glaucoma or ocular hypertension (n = 606)...
journal_title:Current medical research and opinion
pub_type: 杂志文章,多中心研究
doi:10.1185/03007990902816947
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVE:Most patients with hypertension require antihypertensive combination therapy to achieve BP control. This study investigated the safety and efficacy of the direct renin inhibitor aliskiren combined with the calcium channel blocker amlodipine. METHODS:Overall, 556 patients with hypertension (msDBP > or =95-<11...
journal_title:Current medical research and opinion
pub_type: 杂志文章,多中心研究
doi:10.1185/03007990902785845
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVES:Azole antifungal agents are often coadministered with immunosuppressants to recipients of solid organ and hematopoietic stem cell transplants. Posaconazole, an extended-spectrum triazole, is an inhibitor of the cytochrome P450 (CYP) isoenzyme CYP3A4, and sirolimus, an immunosuppressant, is a substrate of the...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007990802644209
更新日期:2009-03-01 00:00:00
abstract:BACKGROUND:Elevated glucose blood levels are the key criteria for diagnosing diabetes mellitus (DM). Hyperglycaemia contributes to the pathophysiology associated with DM, including microvascular and possibly macrovascular disease. In spite of a wide range of pharmacological options available to reduce hyperglycaemia in...
journal_title:Current medical research and opinion
pub_type: 杂志文章,评审
doi:10.1185/03007990802710422
更新日期:2009-03-01 00:00:00
abstract:OBJECTIVES:An economic analysis (based on interim data from a long-term, randomised, multi-centre, controlled, clinical trial) to evaluate chemotherapy with XELOX (capecitabine/oxaliplatin) versus FOLFOX6 (5Fluorouracil/leucovorin/oxaliplatin) as an adjuvant treatment for high risk colorectal cancer patients in Greece....
journal_title:Current medical research and opinion
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1185/03007990902719117
更新日期:2009-03-01 00:00:00
abstract:OBJECTIVE:To investigate the effect of selective laser trabeculoplasty (SLT) on the intraocular pressure (IOP) of untreated fellow eyes in patients with open-angle glaucoma. STUDY DESIGN:Retrospective chart review. PATIENTS AND METHODS:Charts of all patients who underwent SLT at the University of Texas Southwestern M...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007990902728316
更新日期:2009-03-01 00:00:00
abstract:BACKGROUND:The fentanyl HCl iontophoretic transdermal system (ITS) is a patient-controlled analgesic delivery system that actively administers bolus doses of fentanyl transdermally upon patient activation. OBJECTIVE:To determine the amount of fentanyl absorbed from fentanyl ITS via passive absorption over a 24.5-h per...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007990802594941
更新日期:2009-02-01 00:00:00
abstract:BACKGROUND:Physicians and other health care personnel rely on the peer-reviewed biomedical literature as a key source for making clinical decisions. Thus, ensuring that the nonclinical and clinical findings published in biomedical journals are reported accurately and clearly, without undue influence from commercial int...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007990802646584
更新日期:2009-02-01 00:00:00
abstract:BACKGROUND:Tobacco smoking is a major risk factor for cardiovascular disease, respiratory disease and cancer and, for current smokers, smoking cessation is one of the most effective therapeutic interventions for reducing the risk of all-cause morbidity and mortality. However, smoking cessation causes nicotine withdrawa...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007990802707600
更新日期:2009-02-01 00:00:00
abstract:OBJECTIVE:To compare safety and efficacy of biphasic insulin aspart 70/30 (BIAsp 30) with exenatide in subjects with type 2 diabetes mellitus (T2DM) not achieving glycemic targets with metformin and sulfonylurea in a randomized, open-label, 24-week trial. RESEARCH DESIGN AND METHODS:Subjects (N = 372, T2DM > 6 months,...
journal_title:Current medical research and opinion
pub_type: 杂志文章,随机对照试验
doi:10.1185/03007990802597951
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Most patients with hypertension require more than one drug to attain recommended blood pressure (BP) targets. Initiating therapy with two agents is recommended for patients at high risk of a cardiovascular event or with a BP > 20/10 mmHg above goal. Combination therapy is effective when comprised of agents w...
journal_title:Current medical research and opinion
pub_type: 杂志文章,评审
doi:10.1185/03007990802597456
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:Self-reported healthcare resource utilization (HRU), medication out-of-pocket (OOP) expenditures and impact of OOP expenses on HRU were assessed for respondents with type 2 diabetes mellitus (T2DM) or elevated cardiometabolic risk. METHODS:The 5-year longitudinal SHIELD study surveyed a stratified sample of ...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007990802520045
更新日期:2008-12-01 00:00:00
abstract:OBJECTIVE:To provide clinically relevant information on tadalafil 2.5 or 5 mg once daily for the treatment of erectile dysfunction (ED), by reviewing safety and efficacy study findings. Findings from an integrated analysis of trials of tadalafil 10 and 20 mg as needed are presented to provide context for the daily dosi...
journal_title:Current medical research and opinion
pub_type: 杂志文章,评审
doi:10.1185/03007990802498440
更新日期:2008-12-01 00:00:00
abstract:BACKGROUND:The epidemiology and outcome of people hospitalised with a primary diagnosis of psoriasis has never been characterised previously in the United Kingdom. The aim of the study was to characterise the epidemiology of people admitted to hospital with a primary diagnosis of psoriasis. METHODS:Routine hospital da...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007990802583563
更新日期:2008-12-01 00:00:00
abstract:OBJECTIVES:Pioglitazone hydrochloride (Actos † ) and rosiglitazone maleate (Avandia ‡ ) are members of the thiazolidinedione (TZD) class of oral anti-diabetic drugs (OADs) and are used to treat type 2 diabetes mellitus (T2DM). Greater beneficial effects on lipids have been demonstrated with pioglitazone, however. Study...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007990802434874
更新日期:2008-11-01 00:00:00
abstract:OBJECTIVE:The objectives of this article are to review the pathophysiology of type 2 diabetes mellitus (T2DM), present the rationale for a pathophysiologically based treatment approach for patients with T2DM and discuss the role of the therapeutic combination of pioglitazone and exenatide in the management of T2DM. ME...
journal_title:Current medical research and opinion
pub_type: 杂志文章,评审
doi:10.1185/03007990802390795
更新日期:2008-11-01 00:00:00
abstract:OBJECTIVE:This study was aimed at comparing efficacy and tolerance of a new hydrocolloid dressing containing hyaluronic acid (HC + HA) to a reference hydrocolloid not containing hyaluronic acid (HC) in the treatment of leg ulcers of venous or mixed origin. RESEARCH DESIGN AND METHODS:This was an open, prospective stud...
journal_title:Current medical research and opinion
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1185/03007990802367041
更新日期:2008-10-01 00:00:00
abstract:BACKGROUND:In order to reduce individual cardiovascular risk, many patients require life-long lipid-lowering therapy, often as a drug combination approach. We aimed to describe the usage pattern, effectiveness and tolerability of long-term treatment with lipid-lowering agents, with particular focus on an oral combinati...
journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1185/03007990802381406
更新日期:2008-10-01 00:00:00
abstract:OBJECTIVE:The injection force and the patient perception of the Next Generation FlexPen (NGFP) with design modifications aimed at reducing injection force was assessed. The accuracy and precision of the NGFP was also tested under standard conditions. RESEARCH DESIGN AND METHODS:Dosing accuracy was tested (according to...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007990802329264
更新日期:2008-09-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Reduction in total cholesterol (TC) and LDL-cholesterol (LDL-C) forms one of the principal objectives of most cardiovascular secondary prevention strategies. Many patients being treated with statins, however, have significant residual dyslipidaemia, with many having suboptimal HDL-cholesterol ...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007990802374633
更新日期:2008-09-01 00:00:00
abstract:BACKGROUND:Aripiprazole differs from other atypical antipsychotics in its pharmacological and clinical profile. SCOPE:As aripiprazole has been available in the USA for bipolar mania since 2004, clinical experience-sharing from clinical and research use of this agent can assist with initiation and administration in pra...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007990802341426
更新日期:2008-09-01 00:00:00
abstract:OBJECTIVE:To compare injection site pain of subcutaneous (sc) epoetin beta and darbepoetin alfa in adult patients with chronic kidney disease. RESEARCH DESIGN AND METHODS:This was a multi-centre, randomised, two-arm, single-blind, cross-over study. Patients were randomised to receive weekly sc darbepoetin alfa 30 mug ...
journal_title:Current medical research and opinion
pub_type: 杂志文章,随机对照试验
doi:10.1185/03007990802240552
更新日期:2008-08-01 00:00:00
abstract:OBJECTIVE:To investigate the efficacy of pantoprazole 20 mg once daily (o.d.) in relieving epigastric pain associated with ulcer-like functional dyspepsia. RESEARCH DESIGN AND METHODS:In this double-blind, placebo-controlled, multicentre study, patients experiencing ulcer-like functional dyspepsia, with epigastric pai...
journal_title:Current medical research and opinion
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1185/03007990802184545
更新日期:2008-07-01 00:00:00
abstract:BACKGROUND:In clinical practice, persistence with statin therapy is poor. While little is known about relative persistence to specific statins, previous studies have observed greater persistence in patients who achieve greater degrees of lipid lowering. Identification of statin therapies which improve patient persisten...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007990802203279
更新日期:2008-07-01 00:00:00
abstract:OBJECTIVE:This study evaluated the long-term cost-effectiveness of atorvastatin 20 mg, rosuvastatin 10 mg and simvastatin 40 mg in primary and secondary prevention of CHD in Finland. RESEARCH DESIGN AND METHODS:The effect of statin therapy on the incidence of CHD and the expected total costs of the disease were descri...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007990802144705
更新日期:2008-06-01 00:00:00
abstract:OBJECTIVE:To investigate if combined intraocular pressure (IOP)-lowering medication with travoprost/timolol fixed combination and a carbonic anhydrase inhibitor, brinzolamide, is superior to both travoprost monotherapy and travoprost/timolol fixed-combination therapy in primary open-angle glaucoma and ocular hypertensi...
journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章
doi:10.1185/03007990802159273
更新日期:2008-06-01 00:00:00
abstract:BACKGROUND:Reducing low-density lipoprotein cholesterol (LDL-C) levels to National Cholesterol Expert Panel (NCEP) goal is recommended. However, sex-specific effects may influence benefit. METHODS AND RESULTS:In this post hoc analysis of the GREek Atorvastatin and Coronary heart disease (CHD) Evaluation [GREACE] study...
journal_title:Current medical research and opinion
pub_type: 杂志文章,随机对照试验
doi:10.1185/03007990802069563
更新日期:2008-06-01 00:00:00
abstract:OBJECTIVE:To determine the ability of statins to prevent the development of new-onset type 2 diabetes mellitus through a meta-analysis of randomized, controlled trials. RESEARCH DESIGN AND METHODS:A systematic literature search through November 6, 2007 was conducted to identify randomized, placebo-controlled trials of...
journal_title:Current medical research and opinion
pub_type: 信件,评审
doi:10.1185/030079908x292029
更新日期:2008-05-01 00:00:00